Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis
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- 作者：Feng Zhang ; Meng Hao ; Huanhuan Jin ; Zhen Yao ; Naqi Lian ; Li Wu ; Jiangjuan Shao ; Anping Chen and Shizhong Zheng
- 刊名：British Journal of Pharmacology
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：174
- 期：5
- 页码：409-423
- 全文大小：2620K
- ISSN：1476-5381
文摘
Hepatic stellate cells (HSCs) are liver-specific pericytes regulating angiogenesis during liver fibrosis. We aimed to elucidate the mechanisms by which hedgehog signalling regulated HSC angiogenic properties and to validate the therapeutic implications.