Iron-Catalyzed Regioselective Transfer Hydrogenative Couplings of Unactivated Aldehydes with Simple Alkenes
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- 作者：Yan-Long Zheng ; Yan-Yao Liu ; Yi-Mei Wu ; Yin-Xia Wang ; Yu-Tong Lin and Prof. Dr. Mengchun Ye
- 刊名：Angewandte Chemie
- 出版年：2016
- 出版时间：May 17, 2016
- 年：2016
- 卷：128
- 期：21
- 页码：6423-6426
- 全文大小：793K
- ISSN：1521-3757
文摘
An FeBr3-catalyzed reductive coupling of various aldehydes with alkenes that proceeds through a direct hydride transfer pathway has been developed. With iPrOH as the hydrogen donor under mild conditions, previously challenging coupling reactions of unactivated alkyl and aryl aldehydes with simple alkenes, such as styrene derivatives and α-olefins, proceeded smoothly to furnish a diverse range of functionalized alcohols with complete linear regioselectivity.