Ligand-Accelerated Direct C−H Arylation of BINOL: A Rapid One-Step Synthesis of Racemic 3,3′-Diaryl BINOLs

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• 作者：Jin-Fei Yang ; Rong-Hua Wang ; Yin-Xia Wang ; Wei-Wei Yao ; Qi-Sheng Liu and Prof. Dr. Mengchun Ye
• 刊名：Angewandte Chemie
• 出版年：2016
• 出版时间：November 2, 2016
• 年：2016
• 卷：128
• 期：45
• 页码：14322-14326
• 全文大小：1466K
• ISSN：1521-3757

文摘

An ortho-selective rhodium-catalyzed direct C−H arylation of 1,1′-bi-2-naphthol (BINOL), to deliver the widely used but not easily available 3,3′-diaryl BINOL, has been developed. This highly efficient one-step synthetic approach is the shortest route to date and is greatly facilitated by the newly developed ligand system comprising tBu₂PCl, Ph₂-cod, and Cy₃P⋅HBF₄. In addition, the same procedure can facilitate the challenging syntheses of 3-bulkyaryl BINOLs in good to excellent yields.