CD36 is upregulated in mice with periodontitis and metabolic syndrome and involved in macrophage gene upregulation by palmitate

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• 作者：Z Lu ; Y Li ; CW Brinson ; KL Kirkwood ; MF Lopes-Virella and Y Huang
• 刊名：Oral Diseases
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：23
• 期：2
• 页码：210-218
• 全文大小：588K
• ISSN：1601-0825

文摘

We reported that high-fat diet (HFD)-induced metabolic syndrome (MetS) exacerbates lipopolysaccharide (LPS)-stimulated periodontitis and palmitate, the major saturated fatty acid in the HFD, amplified LPS-stimulated gene expression in vitro. As CD36 is a major receptor for fatty acids, we investigated periodontal CD36 expression in mice with periodontitis and MetS, and the role of CD36 in inflammatory gene expression in macrophages stimulated by palmitate.