Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas

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• 作者：Filipe I. Daniel ; Soraia R. Alves ; Daniella S. C. Vieira ; Michelle T. Biz ; Inah W. B. S. Daniel and Filipe Modolo
• 刊名：Journal of Oral Pathology & Medicine
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：45
• 期：10
• 页码：774-779
• 全文大小：624K
• ISSN：1600-0714

文摘

Epigenetic modifications, including DNA methylation of tumor suppressor genes carried out by DNA methyltransferases (DNMTs), are important events in carcinogenesis. Although there are studies concerning to its expression in several cancer types, DNMTs expression pattern is not known in photoinduced lip carcinogenesis. The aim of this study was to investigate the immunoexpression of DNMTs 1, 3a, and 3b in lip precancerous lesion (actinic cheilitis) and cancer.