Development of Biomarker Models to Predict Outcomes in Lupus Nephritis

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• 作者：Bethany J. Wolf ; John C. Spainhour ; John M. Arthur ; Michael G. Janech ; Michelle Petri and Jim C. Oates
• 刊名：Arthritis & Rheumatism
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：68
• 期：8
• 页码：1955-1963
• 全文大小：184K
• ISSN：1529-0131

文摘

The American College of Rheumatology guidelines for the treatment of lupus nephritis recommend change in induction therapy when response to therapy has not occurred within 6 months. Response is not defined, and renal fibrosis can occur while waiting for this end point. Therefore, a decision support tool to better define response is needed to guide clinicians when starting patients on therapy. This study was undertaken to identify biomarker models with sufficient predictive power to develop such a tool.