Rhubarb extract prevents hepatic inflammation induced by acute alcohol intake, an effect related to the modulation of the gut microbiota
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- 作者：Audrey M. Neyrinck ; Usune Etxeberria ; Bernard Taminiau ; Georges Daube ; Matthias Van Hul ; Amandine Everard ; Patrice D. Cani ; Laure B. Bindels and Nathalie M. Delzenne
- 刊名：Molecular Nutrition & Food Research
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：61
- 期：1
- 全文大小：1201K
- ISSN：1613-4133
文摘
Binge consumption of alcohol is an alarming global health problem. Acute ethanol intoxication is characterized by hepatic inflammation and oxidative stress, which could be promoted by gut barrier function alterations. In this study, we have tested the hypothesis of the hepatoprotective effect of rhubarb extract in a mouse model of binge drinking and we explored the contribution of the gut microbiota in the related metabolic effects.