Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: a substudy of the PREDIMED trial
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- 作者：Alexander Medina-Remó ; n ; Rosa Casas ; Anna Tressserra-Rimbau ; Emilio Ros ; Miguel A. Martí ; nez-Gonzá ; lez ; Montserrat Fitó ; Dolores Corella ; Jordi Salas-Salvadó ; Rosa M. Lamuela-Raventos ; Ramó ; n Estruch and on behalf of the PREDIMED Study Investigators
- 刊名：British Journal of Clinical Pharmacology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：83
- 期：1
- 页码：114-128
- 全文大小：1000K
- ISSN：1365-2125
文摘
High dietary polyphenol intake is associated with reduced all-cause mortality and a lower incidence of cardiovascular events. However, the mechanisms involved are not fully understood. The aim of the present substudy of the PREvención con DIetaMEDiterránea (Prevention with Mediterranean diet; PREDIMED) trial was to analyse the relationship between polyphenol intake measured by total urinary polyphenol excretion (TPE), and circulating inflammatory biomarkers and cardiovascular risk factors in elderly individuals. A substudy of 1139 high-risk participants was carried out within the PREDIMED trial. The subjects were randomly assigned to a low-fat control diet or to two Mediterranean diets, supplemented with either extra-virgin olive oil or nuts. Dietary intake, anthropometric data, clinical and laboratory assessments, including inflammatory biomarkers, and urinary TPE were measured at baseline and after the one-year intervention. Participants in the highest tertile of changes in urinary TPE (T3) showed significantly lower plasma levels of inflammatory biomarkers [vascular cell adhesion molecule 1 (VCAM-1) (–9.47 ng ml–1), intercellular adhesion molecule 1 (–14.71 ng ml–1), interleukin 6 (–1.21 pg ml–1), tumour necrosis factor alpha (–7.05 pg ml–1) and monocyte chemotactic protein 1 (–3.36 pg ml–1)] than those inthe lowest tertile (T1, P < 0.02; all). A significant inverse correlation existed between urinary TPE and the plasma concentration of\VCAM-1 (r = –0.301; P < 0.001). In addition, systolic and diastolic blood pressure (BP) decreased and plasma high-density lipoprotein cholesterol increased in parallel with increasing urinary TPE (T3 vs. T1) (P < 0.005 and P = 0.004, respectively). Increases in polyphenol intake measured as urinary TPE are associated with decreased inflammatory biomarkers, suggesting a dose-dependent anti-inflammatory effect of polyphenols. In addition, high polyphenol intake improves cardiovascular risk factors– mainly BP and the lipid profile.