Incidence and impact of subclinical epileptiform activity in Alzheimer's disease
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- 作者：Keith A. Vossel ; Kamalini G. Ranasinghe ; Alexander J. Beagle ; Danielle Mizuiri ; Susanne M. Honma ; Anne F. Dowling ; Sonja M. Darwish ; Victoria Van Berlo ; Deborah E. Barnes ; Mary Mantle ; Anna M. Karydas ; Giovanni Coppola ; Erik D. Roberson ; Bruce L. Miller ; Paul A. Garcia ; Heidi E. Kirsch ; Lennart Mucke and Srikantan S. Nagarajan
- 刊名：Annals of Neurology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：80
- 期：6
- 页码：858-870
- 全文大小：623K
- ISSN：1531-8249
文摘
Seizures are more frequent in patients with Alzheimer's disease (AD) and can hasten cognitive decline. However, the incidence of subclinical epileptiform activity in AD and its consequences are unknown. Motivated by results from animal studies, we hypothesized higher than expected rates of subclinical epileptiform activity in AD with deleterious effects on cognition.