Highly Stereoselective Gold-Catalyzed Coupling of Diazo Reagents and Fluorinated Enol Silyl Ethers to Tetrasubstituted Alkenes
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- 作者：Fu-Min Liao ; Dr. Zhong-Yan Cao ; Dr. Jin-Sheng Yu and Prof. Dr. Jian Zhou
- 刊名：Angewandte Chemie
- 出版年：2017
- 出版时间：February 20, 2017
- 年：2017
- 卷：129
- 期：9
- 页码：2499-2503
- 全文大小：709K
- ISSN：1521-3757
文摘
We report a highly stereoselective synthesis of all-carbon or fluorinated tetrasubstituted alkenes from diazo reagents and fluorinated enol silyl ethers, using C−F bond as a synthetic handle. Cationic AuI catalysis plays a key role in this reaction. Remarkable fluorine effects on the reactivity and selectivity was also observed.