Genome-Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians
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- 作者：Michelle S. Yau ; Laura M. Yerges-Armstrong ; Youfang Liu ; Cora E. Lewis ; David J. Duggan ; Jordan B. Renner ; James Torner ; David T. Felson ; Charles E. McCulloch ; C. Kent Kwoh ; Michael C. Nevitt ; Marc C. Hochberg ; Braxton D. Mitchell ; Joanne M. Jordan and Rebecca D. Jackson
- 刊名：Arthritis & Rheumatism
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：69
- 期：2
- 页码：343-351
- 全文大小：171K
- ISSN：1529-0131
文摘
A major barrier to genetic studies of osteoarthritis (OA) is the need to obtain large numbers of individuals with standardized radiographic evaluations for OA. To address this gap, we performed a genome-wide association study (GWAS) of radiographically defined tibiofemoral knee OA in 3,898 cases and 3,168 controls from 4 well-characterized North American cohorts, and we performed replication analysis of previously reported OA loci.