Lisdexamfetamine Dimesylate Effects on Binge Eating Behaviour and Obsessive-Compulsive and Impulsive Features in Adults with Binge Eating Disorder

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• 作者：Susan L. McElroy ; James E. Mitchell ; Denise Wilfley ; Maria Gasior ; M. Celeste Ferreira-Cornwell ; Michael McKay ; Jiannong Wang ; Timothy Whitaker and James I. Hudson
• 关键词：binge eating disorder ; impulsivity ; lisdexamfetamine dimesylate ; obsessive&ndash ; compulsive
• 刊名：European Eating Disorders Review
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：24
• 期：3
• 页码：223-231
• 全文大小：805K
• ISSN：1099-0968

文摘

In a published 11-week, placebo-controlled trial, 50 and 70 mg/d lisdexamfetamine dimesylate (LDX), but not 30 mg/d LDX, significantly reduced binge eating days (primary endpoint) in adults with binge eating disorder (BED). This report provides descriptions of LDX effects on secondary endpoints (Binge Eating Scale [BES]; Three-Factor Eating Questionnaire [TFEQ]; Yale–Brown Obsessive Compulsive Scale modified for Binge Eating [Y-BOCS-BE]; and the Barratt Impulsiveness Scale, version 11 [BIS-11]) from that study. Week 11 least squares mean treatment differences favoured all LDX doses over placebo on the BES (p ≤ 0.03), TFEQ Disinhibition and Hunger subscales (all p < 0.05), and Y-BOCS-BE total, obsessive, and compulsive scales (all p ≤ 0.02) and on BIS-11 total score at 70 mg/d LDX (p = 0.015) and the TFEQ Cognitive Restraint subscale at 30 and 70 mg/d LDX (both p<0.05). These findings indicate that LDX decreased global binge eating severity and obsessive–compulsive and impulsive features of BED in addition to binge eating days. Copyright