Perturbed Mucosal Immunity and Dysbiosis Accompany Clinical Disease in a Rat Model of Spondyloarthritis

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• 作者：Mark J. Asquith ; Patrick Stauffer ; Sean Davin ; Claire Mitchell ; Phoebe Lin and James T. Rosenbaum
• 刊名：Arthritis & Rheumatism
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：68
• 期：9
• 页码：2151-2162
• 全文大小：610K
• ISSN：1529-0131

文摘

The HLA–B27/β₂-microglobulin (β₂m)–transgenic (Tg) rat is a leading model of B27-associated spondyloarthritis (SpA), and the disease is dependent on the presence of intestinal bacteria. Previous studies have shown that adult HLA–B27/β₂m–Tg rats have an altered intestinal microbiota. This study sought to better define the age-dependent changes to both mucosal immune function and dysbiosis in this rat model of SpA.