Breast Cancer Therapy: Defined Host-Guest Chemistry on Nanocarbon for Sustained Inhibition of Cancer (Small 42/2016)
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- 作者：Fatemeh Ostadhossein ; Santosh K. Misra ; Prabuddha Mukherjee ; Alireza Ostadhossein ; Enrique Daza ; Saumya Tiwari ; Shachi Mittal ; Mark C. Gryka ; Rohit Bhargava and Dipanjan Pan
- 刊名：Small
- 出版年：2016
- 出版时间：November 9, 2016
- 年：2016
- 卷：12
- 期：42
- 页码：5782
- 全文大小：25004K
- ISSN：1613-6829
文摘
A theranostic, enzymatically biodegradable nanoplatform based on luminescent carbon particles decorated with cucurbit[6]uril is introduced for enhancing the solubility of niclosamide, a STAT-3 inhibitor. On page 5845, D. Pan and co-workers reveal that, overall, the supramolecular chemistry on nanocarbon acts as a novel arsenal for STAT-3 inhibition in vitro and in vivo and provides signature intracellular tracking.