Evaluation of a new modified QuEChERS method for the monitoring of carbamate residues in high-fat cheeses by using UHPLC-MS/MS

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• 作者：Ahmed M. Hamed ; David Moreno-Gonz&aacute ; lez ; Laura G&aacute ; miz-Gracia and Ana M. Garc&iacute ; a-Campañ ; a
• 刊名：Journal of Separation Science
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：40
• 期：2
• 页码：488-496
• 全文大小：379K
• ISSN：1615-9314

文摘

A simple and efficient method for the determination of 28 carbamates in high-fat cheeses is proposed. The methodology is based on a modified quick, easy, cheap, effective, rugged, and safe procedure as sample treatment using a new sorbent (Z-Sep⁺) followed by ultra-high performance liquid chromatography with tandem mass spectrometry determination. The method has been validated in different kinds of cheese (Gorgonzola, Roquefort, and Camembert), achieving recoveries of 70–115%, relative standard deviations lower than 13% and limits of quantification lower than 5.4 μg/kg, below the maximum residue levels tolerated for these compounds by the European legislation. The matrix effect was lower than ±30% for all the studied pesticides. The combination of ultra-high performance liquid chromatography and tandem mass spectrometry with this modified quick, easy, cheap, effective, rugged, and safe procedure using Z-Sep⁺ allowed a high sample throughput and an efficient cleaning of extracts for the control of these residues in cheeses with a high fat content.