Molecular epidemiology of enterovirus and parechovirus infections according to patient age over a 4-year period in Spain

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• 作者：Mar&iacute ; a Cabrerizo ; Mar&iacute ; a D&iacute ; az-Cerio ; Carmen Muñ ; oz-Almagro ; N&uacute ; ria Rabella ; David Tarrag&oacute ; Mar&iacute ; a Pilar Romero ; Mar&iacute ; a Jos&eacute ; Pena ; Cristina Calvo ; Sonia Rey-Cao ; Antonio Moreno-Doc&oacute ; n ; In&eacute ; s Mart&iacute ; nez-Rienda ; Almudena Otero and Gloria Trallero
• 刊名：Journal of Medical Virology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：89
• 期：3
• 页码：435-442
• 全文大小：537K
• ISSN：1096-9071

文摘

The epidemiology and clinical association of enterovirus (EV) and parechovirus (HPeV) infections, as well as the type-distribution-according-to-age, were determined during a 4-year study period in Spain. During 2010&ndash;2013, a total of 21,832 clinical samples were screened for EV and the detection frequency was 6.5% (1,430). Of the total EV-negative samples, only 1,873 samples from 2011 to 2013 were available for HPeV testing. HPeV was detected in 42 (2%) of them. Positive samples were genotyped using PCR and sequencing. EV infections occurred in all age groups of patients: neonates (17%), children 28 days to 2 years (29%), children 2&ndash;14 years (40%), and adults (14%). Thirty-four different EV types were identified. HPeV infections were detected exclusively in infants <8 m (70% neonates, P < 0.05). All but one HPeV were HPeV-3. Differences in type frequency detection were found according to age and clinical manifestation. Coxsackievirus (CV)-B4 (61%), CV-B5 (83%), and HPeV-3 (64%) were more frequent in neonates than in older patients (P < 0.05). Echovirus (E)-3 (60%), E-18 (47%), E-25 (62%), CV-A6 (61%), CV-A16 (72%), and EV-71 (75%) were mainly detected in children 28 days to 2 years (P < 0.05), whereas, E-6 (79%), E-20 (88%), and E-30 (85%) were predominant in children >2 years and adults (P < 0.05). Clinically, meningitis was associated with EV (P < 0.01) whereas, encephalitis was more frequent in HPeV-infected patients. CV-B types were associated with myocarditis (90%; P < 0.05) and EV species A with hand&ndash;foot&ndash;mouth-disease/atypical exanthema (88%; P < 0.05). J. Med. Virol. 89:435&ndash;442, 2017.