Atmospheric Pressure Plasma Polymer of Ethyl Lactate: In Vitro Degradation and Cell Viability Studies

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• 作者：Morgane Laurent ; Julia Koehler ; Gad Sabbatier ; Corinne A. Hoesli ; Nicolas Gherardi and Gaé ; tan Laroche
• 刊名：Plasma Processes and Polymers
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：13
• 期：7
• 页码：711-721
• 全文大小：2678K
• ISSN：1612-8869

文摘

Ethyl lactate is injected into a dielectric barrier discharge (DBD) to build up a degradable plasma polymer (PP) to be used as a drug delivery system. Plasma power, deposition time, and type of carrier gas (Ar, N₂) are correlated to the coating in vitro degradation rate. PPs are characterized by AFM, SEM, IR spectroscopy, XPS, and SEC, while surface profilometry is used to monitor the degradation kinetics. PPs deposited under N₂ are mainly composed of hydrophilic functionalities, which explain their fast degradation upon exposure to an aqueous environment. In contrast, PPs synthesized under Ar lead to a slower degradation rate due to their hydrocarbon structure containing some hydrolyzable moieties. The potential of the PPs for vascular applications is verified through cell viability experiments.