Dedifferentiated chordoid meningioma with rhabdomyosarcomatous differentiation on the middle cranial fossa
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- 作者：Hirotaka Fudaba ; Tatsuya Abe ; Masaki Morishige ; Yasutomo Momii ; Kenji Kashima ; Akira Yamada ; Hirofumi Nagatomi ; Atsushi Natsume ; Junko Hirato ; Yoichi Nakazato and Minoru Fujiki
- 刊名：Neuropathology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：36
- 期：6
- 页码：579-583
- 全文大小：643K
- ISSN：1440-1789
文摘
A 46-year-old woman presented with headache and right hemiparesis. MRI demonstrated a mass in the left middle fossa. Total resection was performed. A histological examination of the tumor specimen showed several characteristic morphological features. A chordoid meningioma showing an epithelial-like palisade arrangement was observed. An anaplastic short spindle cell tumor exhibiting a fascicular pattern was considered to be a rhabdomyosarcoma. After conventional radiotherapy, the tumor was well controlled without any neurological deficit for 20 months. When subsequent recurrences were observed, the patient was treated by surgery, stereotactic radiosurgery and chemotherapy. Thirty-two months after the initial treatment, the patient died due to intracranial dissemination and an autopsy was performed. The histological examination of the recurrent and autopsy specimens showed a prominent sarcoma component. This case appears to be the first reported intracranial tumor diagnosed as a dedifferentiated chordoid meningioma with rhabdomyosarcomatous differentiation.