Catalytic Access to Alkyl Bromides, Chlorides and Iodides via Visible Light-Promoted Decarboxylative Halogenation
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- 作者：Dr. Lisa Candish ; Dr. Eric A. Standley ; Dr. Adriá ; n Gó ; mez-Suá ; rez ; Satobhisha Mukherjee and Prof. Dr. Frank Glorius
- 刊名：Chemistry - A European Journal
- 出版年：2016
- 出版时间：July 11, 2016
- 年：2016
- 卷：22
- 期：29
- 页码：9971-9974
- 全文大小：592K
- ISSN：1521-3765
文摘
Herein is reported the catalytic, visible light-promoted, decarboxylative halogenation (bromination, chlorination, and iodination) of aliphatic carboxylic acids. This operationally-simple reaction tolerates a range of functional groups, proceeds at room temperature, and is redox neutral. By employing an iridium photocatalyst in concert with a halogen atom source, the use of stoichiometric metals such as silver, mercury, thallium, and lead can be circumvented. This reaction grants access to valuable synthetic building blocks from the large pool of cheap, readily available carboxylic acids.