5-Hydroxymethylcytosine is a nuclear biomarker to assess biological potential in histologically ambiguous heavily pigmented melanocytic neoplasms
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- 作者：Jonathan J. Lee ; Ricardo E. Vilain ; Scott R. Granter ; Nina R. Hu ; Scott C. Bresler ; Shuyun Xu ; Alexander H. Frank ; Martin C. Mihm Jr ; Robyn P.M. Saw ; Christopher D. Fletcher ; Richard A. Scolyer ; George F. Murphy and Christine G. Lian
- 刊名：Journal of Cutaneous Pathology
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：44
- 期：3
- 页码：249-255
- 全文大小：2612K
- ISSN：1600-0560
文摘
5-Hydroxymethylcytosine (5-hmC) is an epigenetic marker detectable through immunohistochemistry (IHC) that has been shown to distinguish benign nevi from melanoma with high sensitivity and specificity. The purpose of the study was to explore its diagnostic utility in a subset of histologically challenging, heavily pigmented cutaneous melanocytic neoplasms.