ChemInform Abstract: A Concise One-Pot Organo- and Biocatalyzed Preparation of Enantiopure Hexahydrofuro[2,3-b]furan-3-ol: An Approach to the Synthesis of HIV Protease Inhibitors.
The one-pot synthesis of the title species (IV) involves condensation of dihydrofuran with glycolaldehyde dimer (II) followed by lipase-catalyzed kinetic resolution.