Suppression of LIM and SH3 Domain Protein 1 (LASP1) Negatively Regulated by Androgen Receptor Delays Castration Resistant Prostate Cancer Progression

详细信息    查看全文

• 作者：Takashi Dejima ; Kenjiro Imada ; Ario Takeuchi ; Masaki Shiota ; Jeffrey Leong ; Tabitha Tombe ; Kevin Tam ; Ladan Fazli ; Seiji Naito ; Martin E. Gleave and Christopher J. Ong
• 刊名：The Prostate
• 出版年：2017
• 出版时间：February 15, 2017
• 年：2017
• 卷：77
• 期：3
• 页码：309-320
• 全文大小：3690K
• ISSN：1097-0045

文摘

LIM and SH3 domain protein 1 (LASP1) has been implicated in several human malignancies and has been shown to predict PSA recurrence in prostate cancer. However, the anti-tumor effect of LASP1 knockdown and the association between LASP1 and the androgen receptor (AR) remains unclear. The aim of this study is to clarify the significance of LASP1 as a target for prostate cancer, and to test the effect of silencing LASP1 in vivo using antisense oligonucleotides (ASO).