Prospective study of the UGT1A1*27 gene polymorphism during irinotecan therapy in patients with lung cancer: Results of Lung Oncology Group in Kyusyu (LOGIK1004B)
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- 作者：Minoru Fukuda ; Takayuki Suetsugu ; Midori Shimada ; Takeshi Kitazaki ; Kohji Hashiguchi ; Junji Kishimoto ; Taishi Harada ; Takashi Seto ; Noriyuki Ebi ; Koichi Takayama ; Kenji Sugio ; Hiroshi Semba ; Yoichi Nakanishi and Yukito Ichinose
- 刊名：Thoracic Cancer
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：7
- 期：4
- 页码：467-472
- 全文大小：161K
- ISSN：1759-7714
文摘
Uridine 5′-diphospho-glucuronosyltransferase 1A1 (UGT1A1*27) is known to impair the effect of UGT in basic research; however, little clinical investigation has been conducted. To evaluate the effect of the UGT1A1*27 polymorphism in irinotecan therapy, we conducted a prospective study.