Blood Compatibility of Multilayered Polyelectrolyte Films Containing Immobilized Gold Nanoparticles

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• 作者：Arnaud Pallotta ; Marianne Parent ; Igor Clarot ; Ming Luo ; Vincent Borr ; Pan Dan ; Vé ; ronique Decot ; Patrick Menu ; Ramia Safar ; Olivier Joubert ; Pierre Leroy and Ariane Boudier
• 刊名：Particle & Particle Systems Characterization
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：34
• 期：1
• 全文大小：2459K
• ISSN：1521-4117

文摘

Surface material functionalization including layer-by-layer (LbL) polyelectrolyte films with incorporated nanoparticles is a growing field with a wide range of biomedical applications: drug reservoirs, medical devices, or tissue engineering. In parallel, gold nanoparticles (AuNPs) can be grafted by drugs and sensitive molecules using simple protocols. This study shows that AuNP behavior is modified when they are entrapped into three partner LbL films in comparison to the colloidal solution. A polycationic (polyallylamine hydrochloride (PAH)) and a polyanionic (polyacrylic acid (PAA)) polymer is used to build films based on three cycles ((PAH/AuNP/PAA)₃). To investigate the interaction with biomolecules and cells, three different films are developed changing the outer layer (either PAH or AuNP or PAA) with the same number of AuNP deposit. The best biocompatibility is observed with a polyacrylic acid outer layer. Due to the high capacity of drug grafting on gold nanoparticles, the results seem promising for the development of nanostructured biomedical devices.