Ceramide synthase 4 is highly expressed in involved skin of patients with atopic dermatitis

详细信息    查看全文

• 作者：S. Ito ; J. Ishikawa ; A. Naoe ; H. Yoshida ; A. Hachiya ; T. Fujimura ; T. Kitahara and Y. Takema
• 刊名：Journal of the European Academy of Dermatology and Venereology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：31
• 期：1
• 页码：135-141
• 全文大小：345K
• ISSN：1468-3083

文摘

Ceramide is a crucial lipid in the stratum corneum (SC) which maintains the barrier function and hydration of the skin. In atopic dermatitis (AD) patients who have defective skin barrier function, ceramide levels are altered. We previously reported that although the amount of total ceramide was lower in involved skin compared with uninvolved skin of AD patients and with healthy control skin, the amounts of smaller ceramide species of Cer[NS] (<40 total carbons, which are total carbons of both sphingoid base and amide-linked fatty acid), especially Cer[NS] with 34 total carbons (C34-Cer[NS]), were higher. However, the enzyme(s) that produces the higher levels of smaller ceramide species in involved skin of AD patients was unclear.