X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome
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- 作者：Ke Liu ; Biji T. Kurien ; Sarah L. Zimmerman ; Kenneth M. Kaufman ; Diana H. Taft ; Leah C. Kottyan ; Sara Lazaro ; Carrie A. Weaver ; John A. Ice ; Adam J. Adler ; James Chodosh ; Lida Radfar ; Astrid Rasmussen ; Donald U. Stone ; David M. Lewis ; Shibo Li ; Kristi A. Koelsch ; Ann Igoe ; Mitali Talsania ; Jay Kumar ; Jacen S. Maier-Moore ; Valerie M. Harris ; Rajaram Gopalakrishnan ; Roland Jonsson ; James A. Lessard ; Xianglan Lu ; Jacques-Eric Gottenberg ; Juan-Manuel Anaya ; Deborah S. Cunninghame-Graham ; Andrew J. W. Huang ; Michael T. Brennan ; Pamela Hughes ; Gabor G. Illei ; Corinne Miceli-Richard ; Edward C. Keystone ; Vivian P. Bykerk ; Gideon Hirschfield ; Gang Xie ; Wan-Fai Ng ; Gunnel Nordmark ; Per Eriksson ; Roald Omdal ; Nelson L. Rhodus ; Maureen Rischmueller ; Michael Rohrer ; Barbara M. Segal ; Timothy J. Vyse ; Marie Wahren-Herlenius ; Torsten Witte ; Bernardo Pons-Estel ; Marta E. Alarcó ; n-Riquelme ; Joel M. Guthridge ; Judith A. James ; Christopher J. Lessard ; Jennifer A. Kelly ; Susan D. Thompson ; Patrick M. Gaffney ; Courtney G. Montgomery ; Jeffrey C. Edberg ; Robert P. Kimberly ; Graciela S. Alarcó ; n ; Carl L. Langefeld ; Gary S. Gilkeson ; Diane L. Kamen ; Betty P. Tsao ; W. Joseph McCune ; Jane E. Salmon ; Joan T. Merrill ; Michael H. Weisman ; Daniel J. Wallace ; Tammy O. Utset ; Erwin P. Bottinger ; Christopher I. Amos ; Katherine A. Siminovitch ; Xavier Mariette ; Kathy L. Sivils ; John B. Harley and R. Hal Scofield
- 刊名：Arthritis & Rheumatism
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：68
- 期：5
- 页码：1290-1300
- 全文大小：502K
- ISSN：1529-0131
文摘
More than 80% of autoimmune disease predominantly affects females, but the mechanism for this female bias is poorly understood. We suspected that an X chromosome dose effect accounts for this, and we undertook this study to test our hypothesis that trisomy X (47,XXX; occurring in ∼1 in 1,000 live female births) would be increased in patients with female-predominant diseases (systemic lupus erythematosus [SLE], primary Sjögren's syndrome [SS], primary biliary cirrhosis, and rheumatoid arthritis [RA]) compared to patients with diseases without female predominance (sarcoidosis) and compared to controls.