Effects of Gabra2 Point Mutations on Alcohol Intake: Increased Binge-Like and Blunted Chronic Drinking by Mice
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- 作者：Emily L. Newman ; Georgia Gunner ; Polly Huynh ; Darrel Gachette ; Stephen J. Moss ; Trevor G. Smart ; Uwe Rudolph ; Joseph F. DeBold and Klaus A. Miczek
- 刊名：Alcoholism: Clinical and Experimental Research
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：40
- 期：11
- 页码：2445-2455
- 全文大小：492K
- ISSN：1530-0277
文摘
Alcohol use disorders are associated with single-nucleotide polymorphisms in GABRA2, the gene encoding the GABAA receptor α2-subunit in humans. Deficient GABAergic functioning is linked to impulse control disorders, intermittent explosive disorder, and to drug abuse and dependence, yet it remains unclear whether α2-containing GABAA receptor sensitivity to endogenous ligands is involved in excessive alcohol drinking.