Convenient Synthesis of Thieno[3,2-b]indoles and Thieno[3,4-b]indoles by Sequential Site-Selective Suzuki and Double C-N Coupling Reactions

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• 作者：Ngo Nghia Pham ; Silvio Parpart ; Sevak Grigoryan ; Thang Ngoc Ngo ; Tuan Thanh Dang ; Tariel V. Ghochikyan ; Ashot S. Saghyan ; Peter Ehlers and Peter Langer
• 刊名：European Journal of Organic Chemistry
• 出版年：2017
• 出版时间：January 18, 2017
• 年：2017
• 卷：2017
• 期：3
• 页码：538-550
• 全文大小：1635K
• ISSN：1099-0690

文摘

A convenient synthesis of thieno[3,2-b]indoles and thieno[3,4-b]indoles has been developed. The protocol involves a site-selective Suzuki reaction, followed by a double C–N coupling reaction using anilines, benzylamines, or alkylamines. The yields range from good to excellent.