The 7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain
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- 作者：Deniz Bagdas ; Jenny L Wilkerson ; Abhijit Kulkarni ; Wisam Toma ; Shakir AlSharari ; Zulfiye Gul ; Aron H Lichtman ; Roger L Papke ; Ganesh A Thakur and M Imad Damaj
- 刊名：British Journal of Pharmacology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：173
- 期：16
- 页码：2506-2520
- 全文大小：1441K
- ISSN：1476-5381
文摘
Orthosteric agonists and positive allosteric modulators (PAMs) of the α7 nicotinic ACh receptor (nAChR) represent novel therapeutic approaches for pain modulation. Moreover, compounds with dual function as allosteric agonists and PAMs, known as ago-PAMs, add further regulation of receptor function.