Critical influence of the thymus on peripheral T cell homeostasis

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• 作者：Pedro Henrique Oliveira Vianna ; F&aacute ; bio B. Canto ; Jeane S. Nogueira ; Caroline Fraga Cabral Gomes Nunes ; Adriana C&eacute ; sar Bonomo and Rita Fucs
• 刊名：Immunity, Inflammation and Disease
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：4
• 期：4
• 页码：474-486
• 全文大小：745K
• ISSN：2050-4527

文摘

A tight balance between regulatory CD4⁺Foxp3⁺ (Treg) and conventional CD4⁺Foxp3⁻ (Tconv) T cell subsets in the peripheral compartment, maintained stable throughout most of lifetime, is essential for preserving self-tolerance along with efficient immune responses. An excess of Treg cells, described for aged individuals, may critically contribute to their reported immunodeficiency. In this work, we investigated if quantitative changes in thymus emigration may alter the Treg/Tconv homeostasis regardless of the aging status of the peripheral compartment.