What is new in nanoparticle-based photoacoustic imaging?

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• 作者：Jeanne E. Lemaster and Jesse V. Jokerst
• 刊名：Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
• 出版年：2017
• 出版时间：January/February 2017
• 年：2017
• 卷：9
• 期：1
• 全文大小：1114K
• ISSN：1939-0041

文摘

Photoacoustic imaging combines the high temporal and spatial resolution of ultrasound with the good contrast and spectral tuning of optical imaging. Contrast agents are used in photoacoustic imaging to further increase the contrast and specificity of imaging or to image a specific molecular process, e.g., cell-surface proteins or small molecule biomarkers. Nanoparticle-based contrast agents are important tools in photoacoustic imaging because they offer intense and stable signal and can be targeted to specific molecular processes. In this review, we describe some of the most interesting and recent advances in nanoparticle-based photoacoustic imaging including inorganic nanoparticles, organic/polymeric nanoparticles, nanoparticle coatings, multimodality imaging, as well as emerging topics in the field. WIREs Nanomed Nanobiotechnol 2017, 9:e1404. doi: 10.1002/wnan.1404