The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk
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- 作者：Jessica Becker ; Andrea May ; Christian Gerges ; Mario Anders ; Claudia Schmidt ; Lothar Veits ; Tania Noder ; Rupert Mayershofer ; Nicole Kreuser ; Hendrik Manner ; Marino Venerito ; Jan-Hinnerk Hofer ; Orestis Lyros ; Constantin J. Ahlbrand ; Michael Arras ; Sebastian Hofer ; Sophie K. M. Heinrichs ; Katharina Weise ; Timo Hess ; Anne C. Bö ; hmer ; Nils Kosiol ; Ralf Kiesslich ; Jakob R. Izbicki ; Arnulf H. Hö ; lscher ; Elfriede Bollschweiler ; Peter Malfertheiner ; Hauke Lang ; Markus Moehler ; Dietmar Lorenz ; Katja Ott ; Thomas Schmidt ; Markus M. Nö ; then ; Andreas Hackelsberger ; Brigitte Schumacher ; Oliver Pech ; Yogesh Vashist ; Michael Vieth ; Josef Weismü ; ller ; Michael Knapp ; Horst Neuhaus ; Thomas Rö ; sch ; Christian Ell ; Ines Gockel and Johannes Schumacher
- 刊名：Cancer Medicine
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：5
- 期：5
- 页码：888-891
- 全文大小：75K
- ISSN：2045-7634
文摘
Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) represent two stages within the esophagitis-metaplasia-dysplasia-adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic variants confer risk to different stages of the BE/EAC sequence remains mainly unknown. In this study we analyzed three most recently identified BE variants at the genes GDF7 (rs3072), TBX5 (rs2701108), and ALDH1A2 (rs3784262) separately in BE and EAC samples in order to determine their risk effects during BE/EAC sequence. Our data show that rs3072 at GDF7 and rs2701108 at TBX5 are also associated with EAC and conclude that both loci confer disease risk also at later stages of the BE/EAC sequence. In contrast, rs3784262 at ALDH1A2 was highly significantly associated with BE, but showed no association with EAC. Our data do not provide evidence that the ALDH1A2 locus confers equal risk in early and late stages of BE/EAC sequence.