Dietary inflammatory index and risk of epithelial ovarian cancer in African American women

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• 作者：Lauren C. Peres ; Elisa V. Bandera ; Bo Qin ; Kristin A. Guertin ; Nitin Shivappa ; James R. Hebert ; Sarah E. Abbott ; Anthony J. Alberg ; Jill Barnholtz-Sloan ; Melissa Bondy ; Michele L. Cote ; Ellen Funkhouser ; Patricia G. Moorman ; Edward S. Peters ; Ann G. Schwartz ; Paul D. Terry ; Fabian Camacho ; Frances Wang and Joellen M. Schildkraut
• 刊名：International Journal of Cancer
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：140
• 期：3
• 页码：535-543
• 全文大小：180K
• ISSN：1097-0215

文摘

Chronic inflammation has been implicated in the development of epithelial ovarian cancer (EOC); yet the contribution of inflammatory foods and nutrients to EOC risk has been understudied. We investigated the association between the dietary inflammatory index (DII), a novel literature-derived tool to assess the inflammatory potential of one's diet, and EOC risk in African American (AA) women in the African American Cancer Epidemiology Study, the largest population-based case–control study of EOC in AA women to date. The energy-adjusted DII (E-DII) was computed per 1,000 kilocalories from dietary intake data collected through a food frequency questionnaire, which measured usual dietary intake in the year prior to diagnosis for cases or interview for controls. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable logistic regression for the association between the E-DII and EOC risk. 493 cases and 662 controls were included in the analyses. We observed a 10% increase in EOC risk per a one-unit change in the E-DII (OR = 1.10, 95% CI = 1.03–1.17). Similarly, women consuming the most pro-inflammatory diet had a statistically significant increased EOC risk in comparison to the most anti-inflammatory diet (OR_{Quartile4/Quartile1} = 1.72; 95% CI = 1.18–2.51). We also observed effect modification by age (p < 0.05), where a strong, significant association between the E-DII and EOC risk was observed among women older than 60 years, but no association was observed in women aged 60 years or younger. Our findings suggest that a more pro-inflammatory diet was associated with an increased EOC risk, especially among women older than 60 years.