GATA3 expression in primary vulvar Paget disease: a potential pitfall leading to misdiagnosis of pagetoid urothelial intraepithelial neoplasia

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• 作者：Diogo Morbeck ; Aline C Tregnago ; Glauco Baiocchi Netto ; Carlos Sacomani ; Patricia M Peresi ; Cynthia T Osó ; rio ; Luciana Schutz ; Stephania M Bezerra ; Louise de Brot and Isabela W Cunha
• 刊名：Histopathology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：70
• 期：3
• 页码：435-441
• 全文大小：614K
• ISSN：1365-2559

文摘

GATA3 has been reported as a specific urothelial marker among organs in the pelvic region, and has been classified as highly sensitive and specific for urothelial and breast carcinomas. Our aim was to verify GATA3 expression in extramammary Paget disease, and to determine whether it can be use to differentiate primary vulvar Paget disease from pagetoid urothelial intraepithelial neoplasia (PUIN). We also analysed HER2 protein expression and m>HER2m> gene amplification and their roles as prognostic factors in extramammary Paget disease.