Multiple roles for TGFβ receptor type II in regulating the pancreatic response in acute pancreatitis

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• 作者：George K Gittes
• 关键词：acute pancreatitis ; TGF&beta ; signalling ; acinar-to-ductal metaplasia ; pancreatic fibrosis
• 刊名：The Journal of Pathology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：238
• 期：5
• 页码：603-605
• 全文大小：309K
• ISSN：1096-9896

文摘

In their recent publication in Journal of Pathology, Grabliauskaite and Sapanora and their colleagues in Zurich use a conditional ablation of the TGFβ type II receptor (TBRII) to analyse its specific role in pancreatic epithelial cells in response to a caerulein-induced model of acute pancreatitis. These experiments help to clarify some confusion that has existed in the literature stemming from the use of a dominant-negative transgenic TBRII mouse. The results point to a central role for TBRII in acinar cells in mitigating the overall response of the pancreas to the damage and inflammation of acute pancreatitis. Copyright