Endoplasmic reticulum stress is activated in acute pancreatitis

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• 作者：Jian Sheng Wu ; Wei Min Li ; Yi Na Chen ; Qian Zhao and Qin Fen Chen
• 刊名：Journal of Digestive Diseases
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：17
• 期：5
• 页码：295-303
• 全文大小：228K
• ISSN：1751-2980

文摘

Endoplasmic reticulum (ER) is one of the most important cell organelles in the body, regulating protein synthesis, folding and aggregation. Endoplasmic reticulum stress (ERS) is a particular subcellular pathological process involving an imbalance of homeostasis and ER disorder. In the early stage of ERS, cells show a protective unfolded protein response that changes the cellular transcriptional and translational programs to alleviate the process. Therefore, a certain degree of ERS can activate the protective adaptation of cells, whereas sustained severe ERS triggers an apoptotic signal and leads to apoptosis. Acute pancreatitis is a disease caused by trypsin digestion of the pancreas, although the pathogenesis is not completely understood. However, a close association has been suggested between pancreatitis and ERS. This article reviewed relevant research advances and discussed the effect of ERS on the development and progression of acute pancreatitis.