Asparaginase-associated pancreatitis is not predicted by hypertriglyceridemia or pancreatic enzyme levels in children with acute lymphoblastic leukemia

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• 作者：Raheel Altaf Raja ; Kjeld Schmiegelow ; Ditte Nø ; rbo Sø ; rensen and Thomas Leth Frandsen
• 刊名：Pediatric Blood & Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：64
• 期：1
• 页码：32-38
• 全文大小：388K
• ISSN：1545-5017

文摘

l-Asparaginase is an important drug for treatment of childhood acute lymphoblastic leukemia (ALL), but is associated with serious toxicities, including pancreatitis and hypertriglyceridemia (HTG). Asparaginase-associated pancreatitis (AAP) is a common reason for stopping asparaginase treatment. The aim of this study was to explore if HTG or early elevations in pancreatic enzymes were associated with the subsequent development of AAP.