Asymmetric Total Synthesis and Structural Elucidation of Unusual Oxindole Alkaloid Leucolusine

详细信息    查看全文

• 作者：Prof. Ganesh Pandey and Jagadish Khamrai
• 刊名：Asian Journal of Organic Chemistry
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：5
• 期：5
• 页码：621-624
• 全文大小：467K
• ISSN：2193-5815

文摘

The total synthesis of both diastereomers of the unusual tetracyclic ring-opened oxindole alkaloid leucolusine is described. The absolute configuration of the natural leucolusine at the C3 center of the oxindole ring is established by diastereoselective synthesis. Key steps of the synthesis include the synthesis of the piperidine-tetrahydrofuran moiety and construction of leucolusine via N-alkylation of the octahydrofuro[2,3-b]pyridine ring.