The interactions of piperonyl butoxide and analogues with the metabolic enzymes FE4 and CYP6CY3 of the green peach aphid Myzus persicae (Hemiptera: Aphididae)
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- 作者：Michela Panini ; Francesco Tozzi ; Chris Bass ; Christoph T Zimmer ; Linda Field ; Valerio Borzatta ; Emanuele Mazzoni and Graham Moores
- 刊名：Pest Management Science
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：73
- 期：2
- 页码：371-379
- 全文大小：1333K
- ISSN：1526-4998
文摘
Piperonyl butoxide (PBO) is a well-known insecticide synergist capable of interacting with phase 1 metabolic enzymes, specifically esterases and cytochrome P450s. In this study, structure–activity relationship analyses were used to characterise the interaction of around 30 analogues of PBO with the esterase FE4 and the P450 CYP6CY3 from insecticide-resistant Myzus persicae (Sulzer), in order to predict the synthesis of more potent inhibitors.