Paraoxonase 1 Activity Is Modulated by the rs662 Polymorphism and IgG Anti-High-Density Lipoprotein Antibodies in Patients With Rheumatoid Arthritis: Potential Implications for Cardiovascular Disease
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- 作者：Javier Rodrí ; guez-Carrio ; Raquel Ló ; pez-Mejí ; as ; Mercedes Alperi-Ló ; pez ; Patricia Ló ; pez ; Francisco J. Ballina-Garcí ; a ; Miguel Á ; . Gonzá ; lez-Gay and Ana Suá ; rez
- 刊名：Arthritis & Rheumatism
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：68
- 期：6
- 页码：1367-1376
- 全文大小：217K
- ISSN：1529-0131
文摘
Paraoxonase 1 (PON-1) is a high-density lipoprotein (HDL)–associated antioxidant enzyme that plays an important role in HDL-mediated cardioprotection. Although genetic polymorphisms are known to modulate PON-1 activity, its involvement in cardiovascular disease (CVD) in rheumatoid arthritis (RA) is controversial, suggesting that other factors may modulate its function. Since anti-HDL antibodies have been found to be related to an impaired lipid profile and occurrence of CVD in RA, this study was undertaken to examine the associations between PON-1 activity, anti-HDL antibodies, and CVD according to PON1 genetic variants in patients with RA.