Tumor homing indocyanine green encapsulated micelles for near infrared and photoacoustic imaging of tumors
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- 作者：Saji Uthaman ; Joon-suk Bom ; Hyeon Sik Kim ; Johnson V. John ; Hee-Seung Bom ; Seon-Jong Kim ; Jung-Joon Min ; Il Kim and In-Kyu Park
- 关键词：photoacoustic imaging ; indocyanine green ; CD44 receptor ; hyaluronic acid ; near infrared imaging
- 刊名：Journal of Biomedical Materials Research Part B: Applied Biomaterials
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：104
- 期：4
- 页码：825-834
- 全文大小：831K
- ISSN：1552-4981
文摘
Photoacoustic imaging (PAI) is an emerging analytical modality that is under intense preclinical development for the early diagnosis of various medical conditions, including cancer. However, the lack of specific tumor targeting by various contrast agents used in PAI obstructs its clinical applications. In this study, we developed indocyanine green (ICG)-encapsulated micelles specific for the CD 44 receptor and used in near infrared and photoacoustic imaging of tumors. ICG was hydrophobically modified prior to loading into hyaluronic acid (HA)-based micelles utilized for CD 44 based-targeting. We investigated the physicochemical characteristics of prepared HA only and ICG-encapsulated HA micelles (HA-ICG micelles). After intravenous injection of tumor-bearing mice, the bio-distribution and in vivo photoacoustic images of ICG-encapsulated HA micelles accumulating in tumors were also investigated. Our study further encourages the application of this HA-ICG-based nano-platform as a tumor-specific contrast agent for PAI.