Supramolecular Virus-Like Nanorods by Coassembly of a Triblock Polypeptide and Reversible Coordination Polymers

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• 作者：Dr. Armando Hernandez-Garcia ; Prof. Aldrik H. Velders ; Prof. Martien A. Cohen Stuart ; Dr. Renko de Vries ; Dr. Jan W. M. van Lent and Dr. Junyou Wang
• 刊名：Chemistry - A European Journal
• 出版年：2017
• 出版时间：January 5, 2017
• 年：2017
• 卷：23
• 期：2
• 页码：239-243
• 全文大小：1031K
• ISSN：1521-3765

文摘

We investigate a new case of a self-assembly-stimulated self-assembly in which a triblock polypeptide is combined with a anionic coordination polymer of a dipicolinic acid bis-ligand, and d- or f- block metal ions like Zn^II or Eu^III. The polypeptide not only has a silk-like domain that can fold and stack, but also a C-terminal cationic sequence by which it can interact with the supramolecular (coordination) polyanion. In the presence of all three ingredients (polypeptide, bis-ligand, and metal ions), we observe the initiation and slow growth of well-defined metal-containing nanorods of up to 150 nm in length, proving that self-assembly of the polypeptide is triggered by the self-assembly of the coordination polyelectrolyte and vice versa. The particles, which have a striking resemblance to rod-like viruses, are stable up to 1.2 m NaCl, and can be made fluorescent when lanthanides like Eu^III are used, showing the potential to exploit functional properties and applications of virus-like supramolecular structures.