Synthesis, Polymorphism, and Insecticidal Activity of Methyl 4-(4-chlorophenyl)-8-iodo-2-methyl-6-oxo-1,6-dihydro-4H-pyrimido[2,1-b]quinazoline-3-Carboxylate Against Anopheles arabiensis Mosquito

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• 作者：Katharigatta N. Venugopala ; Susanta K. Nayak ; Raquel M. Gleiser ; Mariela E. Sanchez-Borzone ; Daniel A. Garcia and Bharti Odhav
• 刊名：Chemical Biology & Drug Design
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：88
• 期：1
• 页码：88-96
• 全文大小：795K
• ISSN：1747-0285

文摘

Mosquitoes are the major vectors of pathogens and parasites including those causing malaria, the most deadly vector-borne disease. The negative environmental effects of most synthetic compounds combined with widespread development of insecticide resistance encourage an interest in finding and developing alternative products against mosquitoes. In this study, pyrimido[2,1-b]quinazoline derivative DHPM3 has been synthesized by three-step chemical reaction and screened for larvicide, adulticide, and repellent properties against Anopheles arabiensis, one of the dominant vectors of malaria in Africa. The title compound emerged as potential larvicide agent for further research and development, because it exerted 100% mortality, while adulticide activity was considered moderate.