Rotigaptide protects the myocardium and arterial vasculature from ischaemia reperfusion injury
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- 作者：Christian M. Pedersen ; Sowmya Venkatasubramanian ; Henrik Vase ; Janus A. Hyldebrandt ; Hussain Contractor ; Michael R. Schmidt ; Hans Erik Bø ; tker ; Nicholas L. Cruden ; David E. Newby ; Rajesh K. Kharbanda and Ninian N. Lang
- 刊名：British Journal of Clinical Pharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：81
- 期：6
- 页码：1037-1045
- 全文大小：335K
- ISSN：1365-2125
文摘
Ischaemia-reperfusion injury (IRI) causes impaired endothelial function and is a major component of the adverse effects of reperfusion following myocardial infarction. Rotigaptide increases gap junction conductance via connexin-43. We tested the hypothesis that rotigaptide reduces experimental myocardial infarction size and ameliorates endothelial IRI in humans.