Design and Synthesis of “All-in-One” Multifunctional FeS₂ Nanoparticles for Magnetic Resonance and Near-Infrared Imaging Guided Photothermal Therapy of Tumors

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• 作者：Zhouqi Meng ; Fang Wei ; Wujun Ma ; Nuo Yu ; Peiling Wei ; Zhaojie Wang ; Yueqin Tang ; Zhigang Chen ; Huiping Wang and Meifang Zhu
• 刊名：Advanced Functional Materials
• 出版年：2016
• 出版时间：December 6, 2016
• 年：2016
• 卷：26
• 期：45
• 页码：8231-8242
• 全文大小：4021K
• ISSN：1616-3028

文摘

The ideal theranostic nanoplatform for tumors is a single nanoparticle that has a single semiconductor or metal component and contains all multimodel imaging and therapy abilities. The design and preparation of such a nanoparticle remains a serious challenge. Here, with FeS₂ as a model of a semiconductor, the tuning of vacancy concentrations for obtaining “all-in-one” type FeS₂ nanoparticles is reported. FeS₂ nanoparticles with size of ≈30 nm have decreased photoabsorption intensity from the visible to near-infrared (NIR) region, due to a low S vacancy concentration. By tuning their shape/size and then enhancing the S vacancy concentration, the photoabsorption intensity of FeS₂ nanoparticles with size of ≈350 nm (FeS₂-350) goes up with the increase of the wavelength from 550 to 950 nm, conferring the high NIR photothermal effect for thermal imaging. Furthermore, this nanoparticle has excellent magnetic properties for T₂-weighted magnetic resonance imaging (MRI). Subsequently, FeS₂-350 phosphate buffer saline (PBS) dispersion is injected into the tumor-bearing mice. Under the irradiation of 915-nm laser, the tumor can be ablated and the metastasis lesions in liver suffer significant inhibition. Therefore, FeS₂-350 has great potential to be used as novel “all-in-one” multifunctional theranostic nanoagents for MRI and NIR dual-modal imaging guided NIR-photothermal ablation therapy (PAT) of tumors.