Dual-Targeted Photopenetrative Delivery of Multiple Micelles/Hydrophobic Drugs by a Nanopea for Enhanced Tumor Therapy

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• 作者：Chien-Ting Lin ; I-Chieh Lin ; Shou-Yuan Sung ; Yu-Lin Su ; Yu-Fen Huang ; Chi-Shiun Chiang and Shang-Hsiu Hu
• 刊名：Advanced Functional Materials
• 出版年：2016
• 出版时间：June 20, 2016
• 年：2016
• 卷：26
• 期：23
• 页码：4169-4179
• 全文大小：11172K
• ISSN：1616-3028

文摘

A photoresponsive pea-like capsule (nanopea) that also represents a photothermal agent is constructed by wrapping multiple polymer micelles (polyvinyl alcohol, PVA) in reduced graphene oxide nanoshells through a double emulsion approach. Resulting nanopeas can transport multiple PVA micelles containing the fully concealed hydrophobic drug docetaxel (DTX) which can be later released by a near-infrared photoactuation trigger. Through integrating the rod-shaped adhesion and lactoferrin (Lf) targeting, the nanopea enhances both uptake by cancer cellc in vitro and particle accumulation at tumor in vivo. A photopenetrative delivery of micelles/DTX to the tumor site is actuated by NIR irradiation which ruptures the nanopeas as well as releases nanosized micelles/DTX. This trigger also results in thermal damage to the tumor and increases the micelles/DTX permeability, facilitating drug penetration into the deep tumor far from blood vessels for thermal chemotherapy. This nanopea with the capability of imaging, enhanced tumor accumulation, NIR-triggered tumor penetration, and hyperthermia ablation for photothermal chemotherapy boosts tumor treatment and shows potential for use in other biological applications.