Comparison of two automated mononuclear cell collection systems in patients undergoing extracorporeal photopheresis: a prospective crossover equivalence study

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• 作者：Claudia Del Fante ; Luigia Scudeller ; Alberto Martinasso ; Gianluca Viarengo and Cesare Perotti
• 刊名：Transfusion
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：56
• 期：8
• 页码：2078-2084
• 全文大小：174K
• ISSN：1537-2995

文摘

Extracorporeal photopheresis (ECP) is an effective cell therapy employed in several diseases, including graft versus host disease (GVHD) and organ rejection. When ECP is performed using an off-line technique, mononuclear cell (MNC) collection by leukapheresis is necessary for further manipulation (addition of 8-methoxypsoralen and ultraviolet A irradiation before reinfusion to the patient). We report the results of the first crossover equivalence study on yield and purity of MNCs collected from patients undergoing ECP with two different automated systems: MNC and CMNC (working with intermittent and continuous-flow collection, respectively), released by Terumo BCT.