Decreased melanocortin-4 receptor function conferred by an infrequent variant at the human melanocortin receptor accessory protein 2 gene
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- 作者：Laura Schonnop ; Gunnar Kleinau ; Nikolas Herrfurth ; Anna-Lena Volckmar ; Cigdem Cetindag ; Anne Mü ; ller ; Triinu Peters ; Stephan Herpertz ; Jochen Antel ; Johannes Hebebrand ; Heike Biebermann and Anke Hinney
- 刊名：Obesity
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：24
- 期：9
- 页码：1976-1982
- 全文大小：338K
- ISSN：1930-739X
文摘
The melanocortin receptor accessory protein 2 (MRAP2) is relevant for weight regulation in mice and humans. This function is likely mediated by regulation of the melanocortin-4 receptor (MC4R). Functional implications of human m>MRAP2 m> mutations have not been described yet.