A targeted immunomic approach identifies diagnostic antigens in the human pathogen Babesia microti
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- 作者：Emmanuel Cornillot ; Amina Dassouli ; Niseema Pachikara ; Lauren Lawres ; Isaline Renard ; Celia Francois ; Sylvie Randazzo ; Virginie Brè ; s ; Aprajita Garg ; Janna Brancato ; Joseph E. Pazzi ; Jozelyn Pablo ; Chris Hung ; Andy Teng ; Adam D. Shandling ; Vu T. Huynh ; Peter J. Krause ; Timothy Lepore ; Stephane Delbecq ; Gary Hermanson ; Xiaowu Liang ; Scott Williams ; Douglas M. Molina and Choukri Ben Mamoun
- 刊名：Transfusion
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：56
- 期：8
- 页码：2085-2099
- 全文大小：1057K
- ISSN：1537-2995
文摘
Babesia microti is a protozoan parasite responsible for the majority of reported cases of human babesiosis and a major risk to the blood supply. Laboratory screening of blood donors may help prevent transfusion-transmitted babesiosis but there is no Food and Drug Administration–approved screening method yet available. Development of a sensitive, specific, and highly automated B. microti antibody assay for diagnosis of acute babesiosis and blood screening could have an important impact on decreasing the health burden of B. microti infection.