Evidence of benefits from using fresh and cryopreserved blood to transfuse patients with acute sickle cell disease
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- 作者：Philippe Chadebech ; Marie-Amé ; lie de Mé ; norval ; Gwellaouen Bodivit ; Armand Mekontso-Dessap ; Sadaf Pakdaman ; Alicia Jouard ; Fré ; dé ; ric Galacté ; ros ; Philippe Bierling ; Anoosha Habibi and France Pirenne
- 刊名：Transfusion
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：56
- 期：7
- 页码：1730-1738
- 全文大小：416K
- ISSN：1537-2995
文摘
The transfusion of red blood cell (RBC) concentrates is the main treatment for acute vaso-occlusive symptoms in sickle cell disease (SCD). Units of packed RBCs (pRBCs) must retain optimal characteristics for transfusion throughout the storage period. Transfused RBCs interact with the plasma and the endothelium that lines blood vessels and may be the target of immune-hematologic conflict if the patient produces antibodies against RBCs. Questions remain concerning the benefit-risk balance of RBC transfusions, in particular about the shelf-life of the units.